401(k) · DOL Form 5500 · 2022

Karyopharm Therapeutics Inc. 401(k) Plan

Data updated 2026-08-25

$36M
Total assets Below avg plan size
405
Participants Below avg headcount
85th
Percentile by assets National rank
$88,994
Avg per participant Below avg balance/head
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Official DOL plan name: Karyopharm Therapeutics Inc. 401(k) Plan · Sponsored by Karyopharm Therapeutics Inc. · Massachusetts · Manufacturing

$36M in assets, 405 participants

Karyopharm Therapeutics Inc.'s Karyopharm Therapeutics Inc. 401(k) Plan reported $36M in total assets and 405 participants in its 2022 DOL Form 5500 filing, ranking in the 85th percentile by assets among filed plans. Figures are as reported by the plan sponsor to the Department of Labor, not audited or endorsed by PlainRetire.

  • #16,138 in Manufacturing (20,602 peers)

Where Karyopharm Therapeutics Inc. 401(k) Plan sits by assets

Karyopharm Therapeutics Inc. 401(k) Plan sits in the top quartile of all filed plans by assets, $36M for 405 participants (~$88,994/participant), down 7.5% in 2022.

#16,138
in Manufacturing (20,602 peers)
-7.5%
assets change YoY
0.4×
vs typical plan assets (national mean)

The plan reported a net loss of $3M for the year, a single-year figure driven by markets and benefit payments, not a measure of plan health.

Karyopharm Therapeutics Inc. 401(k) Plan's outsized position by total assets

Karyopharm Therapeutics Inc. 401(k) Plan vs every filed plan by assets

End-of-year total assets · plan year 2022 · DOL Form 5500

$36,042,620 Top 15% higher than 85% of 139,123 filed plans

This plan $0 $2,050,000,000 every filed plan with reported assets, bucketed by value

Dashed line + filled bar = this entry, among filed plans.

Source U.S. Department of Labor Form 5500 filings (EBSA) · plan year 2022

Karyopharm Therapeutics Inc. 401(k) Plan among mid-size filed plans by headcount

Plan-year 2022 Form 5500 filings with a reported participant count, partitioned by headcount band, not by assets. Karyopharm Therapeutics Inc. 401(k) Plan sits mid-pack in the medium band (405 participants).

Published 5500 schedule card

Filing strip 263931704 · Karyopharm Therapeutics Inc. PY 2022 · 401(k)

Karyopharm Therapeutics Inc. 401(k) Plan · $36M · 405 · 85th

  • EOY $36M
  • EOY 405
  • EOY 85th
  • EOY 401(k)
  • EOY near Cox Operating, LLC 401(k) P/S Plan
  • EOY ind #16138

Stamps derive from this plan's Form 5500 line items (assets, participants, type, EIN, cohort placement) - not a quality rating of the sponsor. Read with Manufacturing retirement plans → · Plans in Massachusetts →

Karyopharm Therapeutics Inc. 401(k) Plan in the asset neighbourhood

Cox Operating, LLC 401(k) P/S PlanCox Operating, LLC 401(k) P/…$36MAbo Leasing Corporation 401(k) Profit Sharing Plan and TrustAbo Leasing Corporation 401(…$36MOld Pueblo Anesthesia, P.C. Savings PlanOld Pueblo Anesthesia, P.C. …$36MKaryopharm Therapeutics Inc. 401(k) PlanKaryopharm Therapeutics Inc.…$36MContainer Graphics Corporation Retirement and Savings PlanContainer Graphics Corporati…$36M
End-of-year total assets ($M) among Karyopharm Therapeutics Inc. 401(k) Plan and nearest nationwide 401(k) peers. Source: DOL Form 5500 plan year 2022.

Scale-class filing particulars (2022)

Total Assets (Beginning of Year)$39M
Net Assets (End of Year)$36M
Net Income-$3M
Employer EIN263931704
Plan Effective Date2011-01-01
Filing StatusFILING RECEIVED

Sponsor Plan History (Karyopharm Therapeutics Inc.)

Sponsor-wide plan assets over time

All Karyopharm Therapeutics Inc. plans reported in each filing year

Latest sponsor-wide plan assets
$56M 54.337162503724755% vs 2022
2024 filing year
$30M$40M$50M$60M 202220232024 $36M $55.6M ▲ +54.4%
Year Plans Participants Total Assets
2022 1 405 $36M
2023 1 401 $46M
2024 1 308 $56M

Nearby 401(k) Plans in Massachusetts

Peer 401(k) plans, same state, same plan type, ranked by total assets.

Karyopharm Therapeutics Inc. 401(k) Plan vs. nearby 401(k) plans in Massachusetts, assets vs. participants Scatter plot of 6 data points. -200000200004000060000 -100102030 Total assets ($B) Participants Karyopharm Therapeutics Inc. 401(k) Plan, Total assets ($B): 0.03604262 · Participants: 405Karyopharm Therapeutics Inc. 401(k) PlanFidelity Retirement Savings Plan, Total assets ($B): 22.953563448 · Participants: 52036Fidelity Retirement Savings PlanLiberty Mutual 401(k) Plan, Total assets ($B): 8.79802945 · Participants: 32843Liberty Mutual 401(k) PlanMassachusetts Institute of Technology Supplemental 401(k) Plan, Total assets ($B): 5.810585521 · Participants: 13690Massachusetts Institute of Technology Supplemental 401(k) PlanPhilips North America 401(k) Plan, Total assets ($B): 5.180251859 · Participants: 19750Philips North America 401(k) PlanBoston Scientific Corporation 401(k) Retirement Savings Plan, Total assets ($B): 4.853752256 · Participants: 18359Boston Scientific Corporation 401(k) Retirement Savings Plan
Karyopharm Therapeutics Inc. 401(k) Plan vs. nearby 401(k) plans in Massachusetts, assets vs. participants
Compare Karyopharm Therapeutics Inc. 401(k) Plan side-by-side with 3 peers →

Karyopharm Therapeutics Inc. 401(k) Plan's out-of-state 401(k) peers by assets and headcount

Outside Massachusetts, the nearest 401(k) by assets is Cox Operating, LLC 401(k) P/S Plan in TX ($36M); by covered participants it is Pennock Hospital 401(a) Retirement Plan in MI (405 participants). Same-state nearby plans are listed separately above.

Similar participant headcount

Nearest other-state filings by covered participants (405 participants); asset peers above are excluded.

DOL Form 5500 plan year 2022. Asset totals can differ widely at the same headcount; neither axis is a quality rating.

Frequently Asked Questions

How did Karyopharm Therapeutics Inc. 401(k) Plan assets move in 2022? ▼
Karyopharm Therapeutics Inc. 401(k) Plan pulled back noticeably - down 7.5% during 2022, from $39M to $36M. Reported net income was -$3M.
How have Karyopharm Therapeutics Inc. plan assets changed over time? ▼
Across 3 plan years on file (2022-2024), Karyopharm Therapeutics Inc.'s sponsor-wide assets grew 54.3%, from $36M to $56M.
Where does Karyopharm Therapeutics Inc. 401(k) Plan rank by assets among Form 5500 filers? ▼
Karyopharm Therapeutics Inc. 401(k) Plan ranks in the 85th percentile by end-of-year assets among 139,126 plans that reported assets for plan year 2022 (in the top quartile of all filed plans by assets).
Which 401(k) plans are similar in size to Karyopharm Therapeutics Inc. 401(k) Plan? ▼
Among 401(k) plans in other states, the closest by assets is Cox Operating, LLC 401(k) P/S Plan in TX ($36M, 421 participants).
Which 401(k) plans cover a similar participant headcount to Karyopharm Therapeutics Inc. 401(k) Plan? ▼
Among 401(k) plans in other states, the closest by covered participants is Pennock Hospital 401(a) Retirement Plan in MI (405 participants, $317K in assets).

Source: U.S. Department of Labor, Employee Benefits Security Administration (EBSA), Form 5500 public disclosure dataset. Plan year 2022.

Source: DOL EFAST2 filing system (efast.dol.gov) - original filing retrieval by EIN 263931704.

Read our methodology - how this data is sourced, computed, and verified.

Data sourced from U.S. Department of Labor Form 5500 filings (EBSA). See our methodology for details.